# CAPRYL/CAPRAMIDOPROPYL BETAINE (capryl-capramidopropyl-betaine) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/capryl-capramidopropyl-betaine
- **Standard INCI**: `CAPRYL/CAPRAMIDOPROPYL BETAINE`
- **KR MFDS Standard Name**: `카프릴/카프라미도프로필베타인`
- **CAS No.**: `N/A`
- **EC / EINECS No.**: `N/A`
- **Origin**: `synthetic`
- **Functions**: 대전방지제, 세정제, 모발컨디셔닝제, 피부컨디셔닝제, 거품증진제, 점도조절제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 카프릴/카프라미도프로필베타인 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | CAPRYL/CAPRAMIDOPROPYL BETAINE |
| US (PCPC / MoCRA INCI) | CAPRYL/CAPRAMIDOPROPYL BETAINE |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 辛酰/癸酰氨丙基甜菜碱 |
| JP (JCIA / MHLW QD) | CAPRYL/CAPRAMIDOPROPYL BETAINE  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `none` (Entry: `7213`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- Listed within general cosmetic GMP safety thresholds.

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8
- **Max Process Temp**: ≤ 50°C
- **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL
- **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: CAPRYL/CAPRAMIDOPROPYL BETAINE | CAS No.: N/A | EC No.: N/A
  - Origin: SYNTHETIC | Functions: , , , , , 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [CAPRYL/CAPRAMIDOPROPYL BETAINE] · EU [CAPRYL/CAPRAMIDOPROPYL BETAINE] · CN [辛酰/癸酰氨丙基甜菜碱] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - N-(3-Decanoyl(or octanoyl)aminopropyl)-N-carboxymethyl-N,N-dimethyl-1-propanaminium inner salts Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver , , , , ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: NONE | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 7213 (辛酰/癸酰氨丙基甜菜碱))
  - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment).
  - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [cleanser_rinse] Typical range: 1.0 ~ 35.0% (Median 5.35%, Ref: Global Starter Formulation Library Statistical Distribution (n=30, EVONIK 30)) — Rinse-off cleanser & surfactant system modifier
  - [emulsion_cream] Typical range: 0.8 ~ 2.0% (Median 1.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=7, EVONIK 7)) — Emulsion cream & lotion structural / conditioning agent
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Cool-down Phase (< 45°C)
  - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads
  - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: CAPRYL/CAPRAMIDOPROPYL BETAINE
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 33259636 (2021, Int J Cosmet Sci): Optimizing interactions between soluble silk fibroin and capryl glucoside for design of a natural and high-performance c

## 6. Linked PubMed Literature
- [PMID: 33259636] Optimizing interactions between soluble silk fibroin and capryl glucoside for design of a natural and high-performance co-surfactant system. — *Int J Cosmet Sci* (2021)