# C12-15 ALKYL BENZOATE (c12-15-alkyl-benzoate) — Global Cosmetic Regulatory & Formulation Monograph - **Canonical URL**: https://www.inciname.com/en/ingredients/c12-15-alkyl-benzoate - **Standard INCI**: `C12-15 ALKYL BENZOATE` - **KR MFDS Standard Name**: `C12-15알킬벤조에이트` - **CAS No.**: `68411-27-8` - **EC / EINECS No.**: `270-112-4` - **Origin**: `synthetic` - **Functions**: 항균제, 피부컨디셔닝제, 에모리엔트 - **Molecular Formula / MW**: `—` (— g/mol) ## 1. 7-Track Official Regulatory Label Names | Track | Official Label Nomenclature | | :--- | :--- | | KR (MFDS Standard) | C12-15알킬벤조에이트 | | KR (Former Names) | — | | EU (CosIng 1223/2009) | C12-15 ALKYL BENZOATE | | US (PCPC / MoCRA INCI) | C12-15 ALKYL BENZOATE | | US (FDA OTC Monograph) | — | | CN (NMPA IECIC) | C12-15 醇苯甲酸酯 | | JP (JCIA / MHLW QD) | C12-15 ALKYL BENZOATE | ## 2. Layer 1 — Global 6-Region Statutory Summary - **KR (MFDS)**: `none` - **EU (1223/2009)**: `none` - **US (FDA/MoCRA)**: `none` - **CN (NMPA IECIC)**: `allowed` (Entry: `134`) - **JP (MHLW)**: `none` - **ASEAN (ACD)**: `none` ## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations - **reported_use** (total): 0.0008~59% — 116_draft_alkyl.pdf (null) - **reported_use** (leave_on): 0.0008~59% — 116_draft_alkyl.pdf (null) - **reported_use** (rinse_off): 0.1~50% — 116_draft_alkyl.pdf (null) - **reported_use** (eye): 0.0008~11% — 116_draft_alkyl.pdf (null) - **reported_use** (ingestion): 3~16% — 116_draft_alkyl.pdf (null) - **reported_use** (spray): 0.3~12% — 116_draft_alkyl.pdf (null) - **reported_use** (dermal): 0.0008~59% — 116_draft_alkyl.pdf (null) - **reported_use** (deodorant): 0.004~12% — 116_draft_alkyl.pdf (null) - **reported_use** (hair): 0.3~35% — 116_draft_alkyl.pdf (null) - **reported_use** (hair_dye): 0.5~2% — 116_draft_alkyl.pdf (null) - **reported_use** (nail): 0.008~10% — 116_draft_alkyl.pdf (null) - **reported_use** (mucous): 0.01~0.04% — 116_draft_alkyl.pdf (null) - **reported_use** (baby): 10~10% — 116_draft_alkyl.pdf (null) - **reported_use** (bath): 0.008~10% — 117_tent_benzoa.pdf (null) - **cn_iecic_max** (leave_on): ≤ 30% — NMPA IECIC (2025) Entry 00971 (2025) - **cn_iecic_max** (rinse_off): ≤ 15% — NMPA IECIC (2025) Entry 00971 (2025) ## 4. Layer 3 — Formulation Quartiles & Compatibility - **Optimal pH Window**: 4 – 8 - **Max Process Temp**: ≤ 50°C - **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL - **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads ## 5. Academic Monograph ■ [1. Chemical Identity & International Labeling Nomenclature] - INCI Name: C12-15 ALKYL BENZOATE | CAS No.: 68411-27-8 | EC No.: 270-112-4 - Origin: SYNTHETIC | Functions: , , - Physicochemical Profile: Formula | MW /(Polymer/Complex) | / | Ionic Nature: non-ionic | CosIng/MFDS - Official Regional Label Names: US [C12-15 ALKYL BENZOATE] · EU [C12-15 ALKYL BENZOATE] · CN [C12-15 醇苯甲酸酯] · JP [-] · JP Quasi-Drug [-] ■ [2. Dermatological Mechanism of Action & Functional Role] - Benzoic acid, C12-15 alkyl esters Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver , , performance and structural formulation stability. ■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)] - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 134 (C12-15 醇苯甲酸酯)) - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment). - Official Safety & Historical Use Concentration (Layer 2): cir (reported_use, total): 0.0008~59% / cir (reported_use, leave_on): 0.0008~59% / cir (reported_use, rinse_off): 0.1~50% ■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)] - [aqueous_serum] Typical range: 2.0 ~ 20.0% (Median 4.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=8, ELEMENTIS 5 · SEPPIC 3)) — Aqueous serum, toner & hydrogel matrix formulation component - [sun_color] Typical range: 3.0 ~ 20.0% (Median 8.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=8, ELEMENTIS 3 · GRANT 3 · EVONIK 1 · SEPPIC 1)) — Sun care & color cosmetics dispersion / sensory modifier ■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)] - Addition Phase: Water Phase or Cool-down Phase (< 45°C) - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: C12-15 ALKYL BENZOATE ■ [6. Peer-Reviewed Literature & Official Compendia Evidence] - PMID 40504031 (2025, Toxicol Sci): Dermal absorption and metabolism of 14C-C12 alkyl benzoate in Finsolv TN in human skin in vitro - PMID 32065958 (2020, J Photochem Photobiol B): Effect of emollients on UV filter absorbance and sunscreen efficiency - PMID 25943945 (2015, Contact Dermatitis): C12-15 alkyl benzoate: a new cosmetic allergen? ## 6. Linked PubMed Literature - [PMID: 40504031] Dermal absorption and metabolism of 14C-C12 alkyl benzoate in Finsolv TN in human skin in vitro — *Toxicol Sci* (2025) - [PMID: 32065958] Effect of emollients on UV filter absorbance and sunscreen efficiency — *J Photochem Photobiol B* (2020) - [PMID: 25943945] C12-15 alkyl benzoate: a new cosmetic allergen? — *Contact Dermatitis* (2015) - [PMID: 18161634] Stability of benzoyl peroxide in aromatic ester-containing topical formulations — *Pharm Dev Technol* (2007)