# BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE (bis-ethylhexyloxyphenol-methoxyphenyl-triazine) — Global Cosmetic Regulatory & Formulation Monograph - **Canonical URL**: https://www.inciname.com/en/ingredients/bis-ethylhexyloxyphenol-methoxyphenyl-triazine - **Standard INCI**: `BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE` - **KR MFDS Standard Name**: `비스-에칠헥실옥시페놀메톡시페닐트리아진` - **CAS No.**: `187393-00-6` - **EC / EINECS No.**: `N/A` - **Origin**: `synthetic` - **Functions**: 모발컨디셔닝제, 자외선차단제, 광안정제 - **Molecular Formula / MW**: `C38H49N3O5` (627.81 g/mol) ## 1. 7-Track Official Regulatory Label Names | Track | Official Label Nomenclature | | :--- | :--- | | KR (MFDS Standard) | 비스-에칠헥실옥시페놀메톡시페닐트리아진 | | KR (Former Names) | — | | EU (CosIng 1223/2009) | BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE | | US (PCPC / MoCRA INCI) | BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE | | US (FDA OTC Monograph) | BEMOTRIZINOL (UNAPPROVED OTC IN US) | | CN (NMPA IECIC) | 双-乙基己氧苯酚甲氧苯基三嗪 | | JP (JCIA / MHLW QD) | BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE | ## 2. Layer 1 — Global 6-Region Statutory Summary - **KR (MFDS)**: `restricted` - **EU (1223/2009)**: `restricted` - **US (FDA/MoCRA)**: `banned` - **CN (NMPA IECIC)**: `restricted` (Entry: `6251`) - **JP (MHLW)**: `restricted` - **ASEAN (ACD)**: `restricted` ## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations - Listed within general cosmetic GMP safety thresholds. ## 4. Layer 3 — Formulation Quartiles & Compatibility - **Optimal pH Window**: 4 – 8.5 - **Max Process Temp**: ≤ 85°C - **Synergy Pairings**: DIETHYLAMINO HYDROXYBENZOYL HEXYL BENZOATE, ETHYLHEXYL TRIAZONE, DICAPRYLYL CARBONATE, C12-15 ALKYL BENZOATE - **Incompatibilities**: Requires sufficient polar ester solvents (Dicaprylyl Carbonate, C12-15 Alkyl Benzoate, Dibutyl Adipate) heated to 75~80°C to prevent recrystallization; REGULATORY ALERT: Approved up to 10% in KR/EU/CN/JP/ASEAN, but NOT YET listed in US FDA OTC Sunscreen Monograph M020 ## 5. Academic Monograph ■ [1. Chemical Identity & International Labeling Nomenclature] - INCI Name: BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE | CAS No.: 187393-00-6 | EC No.: N/A - Origin: SYNTHETIC | Functions: , , - Physicochemical Profile: Formula C38H49N3O5 | MW 627.81 g/mol | LogP 10.4 | Ionic Nature: non-ionic | PubChem CID 135483542 - Official Regional Label Names: US [BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE] · EU [BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE] · CN [双-乙基己氧苯酚甲氧苯基三嗪] · JP [-] · JP Quasi-Drug [-] ■ [2. Dermatological Mechanism of Action & Functional Role] - Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine is the heterocyclic compound that conforms to the formula: Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver , , performance and structural formulation stability. ■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)] - Regional Summary: KR: RESTRICTED | EU: RESTRICTED | US: BANNED | CN: RESTRICTED | JP: RESTRICTED | ASEAN: RESTRICTED (CN IECIC (2025) Entry No. 6251 (双-乙基己氧苯酚甲氧苯基三嗪)) - [CN / COMPOSITION / limited] (Max 10%): - [KR / COMPOSITION / limited] (Max 10%): - [EU / COMPOSITION / limited] (Max 10%): - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins ■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)] - [sun_color] Typical range: 1.0 ~ 10.0% (Median 3.0%, Ref: BASF Tinosorb S Technical Monograph & EU Annex VI #25) — Broad-spectrum photostable UVA/UVB organic filter & Avobenzone photostabilizer (Max 10%) ■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)] - Addition Phase: Oil Phase (Heat to 75~80°C in high-polarity esters until 100% dissolved) - Optimal pH Range: pH 4.0 ~ 8.5 | Max Process Temp: Max 85°C | Electrolyte Tolerance: HIGH - Incompatibility / Caution: Requires sufficient polar ester solvents (Dicaprylyl Carbonate, C12-15 Alkyl Benzoate, Dibutyl Adipate) heated to 75~80°C to prevent recrystallization - Incompatibility / Caution: REGULATORY ALERT: Approved up to 10% in KR/EU/CN/JP/ASEAN, but NOT YET listed in US FDA OTC Sunscreen Monograph M020 - Synergy Pairings: DIETHYLAMINO HYDROXYBENZOYL HEXYL BENZOATE, ETHYLHEXYL TRIAZONE, DICAPRYLYL CARBONATE, C12-15 ALKYL BENZOATE | Reference Trade Names: Tinosorb® S (BASF), PARSOL® Shield (DSM), BEMT ■ [6. Peer-Reviewed Literature & Official Compendia Evidence] - PMID 42189146 (2026, Phys Chem Chem Phys): Synergistic effect of anomalous solvatochromism and fast relaxation on the enhancement of BEMT UV photoprotection perfor - PMID 40782226 (2025, Environ Sci Pollut Res Int): Marine sediments microbes degrade a limited repertoire of organic UV filters - PMID 39011994 (2024, Contact Dermatitis): Allergic contact dermatitis to bis-ethylhexyloxyphenol methoxyphenyl triazine (Tinosorb S) in a sunscreen: An emerging a ## 6. Linked PubMed Literature - [PMID: 42189146] Synergistic effect of anomalous solvatochromism and fast relaxation on the enhancement of BEMT UV photoprotection performance — *Phys Chem Chem Phys* (2026) - [PMID: 40782226] Marine sediments microbes degrade a limited repertoire of organic UV filters — *Environ Sci Pollut Res Int* (2025) - [PMID: 39011994] Allergic contact dermatitis to bis-ethylhexyloxyphenol methoxyphenyl triazine (Tinosorb S) in a sunscreen: An emerging allergen? — *Contact Dermatitis* (2024) - [PMID: 36738872] Preliminary clinical pharmacokinetic evaluation of bemotrizinol - A new sunscreen active ingredient being considered for inclusion under FDA's over-the-counter (OTC) sunscreen monograph — *Regul Toxicol Pharmacol* (2023) - [PMID: 36152716] Assessing the eco-compatibility of new generation sunscreen products through a combined microscopic-molecular approach — *Environ Pollut* (2022) - [PMID: 35306675] Allergic contact dermatitis caused by dimethicodiethylbenzalmalonate (polysilicone-15, 　Parsol  SLX) and bis-ethylhexyloxyphenol methoxyphenyl triazine (Tinosorb S) in sunscreen cream — *Contact Dermatitis* (2022) - [PMID: 35189223] Evaluation of the degradation capacity of WWTP sludge enrichment cultures towards several organic UV filters and the isolation of octocrylene-degrading microorganisms — *Sci Total Environ* (2022) - [PMID: 34227762] Simultaneous determination of 22 sunscreen agents in cosmetics by ultra-high-performance liquid chromatography using diode array detector — *Se Pu* (2021) - [PMID: 33555472] Exposure to four chemical UV filters through contaminated sediment: impact on survival, hatching success, cardiac frequency, and aerobic metabolic scope in embryo-larval stage of zebrafish — *Environ Sci Pollut Res Int* (2021) - [PMID: 33399219] Ultraviolet filters in sunscreens and cosmetic products-A market survey — *Contact Dermatitis* (2021) - [PMID: 33276055] Animal- free skin permeation analysis using mass spectrometry imaging — *Toxicol In Vitro* (2021) - [PMID: 33300922] Insights into the stabilization of photolabile UV-absorbers in sunscreens — *Photochem Photobiol Sci* (2020)