# BHT (bht) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/bht
- **Standard INCI**: `BHT`
- **KR MFDS Standard Name**: `비에이치티`
- **CAS No.**: `128-37-0`
- **EC / EINECS No.**: `204-881-4`
- **Origin**: `synthetic`
- **Functions**: 항산화제, 향료
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 비에이치티 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | BHT |
| US (PCPC / MoCRA INCI) | BHT |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 丁羟甲苯 |
| JP (JCIA / MHLW QD) | ＢＨＴ (QD: ジブチルヒドロキシトルエン) |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `restricted`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `1964`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`

- **EU** [limited]: ≤ 0.8% —  (Regulation (EC) No 1223/2009 Annex III — via CosIng (EU Commission))

## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- **reported_use** (mouthwash): ≤ 0.001% — undefined (undefined)
- **reported_use** (toothpaste): ≤ 0.1% — undefined (undefined)
- **cn_iecic_max** (leave_on): ≤ 0.5% — NMPA IECIC (2025) Entry 01912 (2025)
- **cn_iecic_max** (rinse_off): ≤ 0.5% — NMPA IECIC (2025) Entry 01912 (2025)

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8
- **Max Process Temp**: ≤ 50°C
- **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL
- **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: BHT | CAS No.: 128-37-0 | EC No.: 204-881-4
  - Origin: SYNTHETIC | Functions: , 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [BHT] · EU [BHT] · CN [丁羟甲苯] · JP [ＢＨＴ] · JP Quasi-Drug [ジブチルヒドロキシトルエン]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - BHT is a substituted toluene that conforms to the formula: Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: RESTRICTED | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 1964 (丁羟甲苯))
  - [EU / COMPOSITION / limited] (Max 0.8%): 
  - Official Safety & Historical Use Concentration (Layer 2): sccs (reported_use, mouthwash): Max 0.001% / sccs (reported_use, toothpaste): Max 0.1% / CN_IECIC_2025 (cn_iecic_max, leave_on): Max 0.5%
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [emulsion_cream] Typical range: 0.02 ~ 0.5% (Median 0.02%, Ref: Global Starter Formulation Library Statistical Distribution (n=5, GRANT 4 · SEPPIC 1)) — Emulsion cream & lotion structural / conditioning agent
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Cool-down Phase (< 45°C)
  - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads
  - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: BHT
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 41303448 (2025, Int J Mol Sci): Synthesis and Evaluation of Powerful Antioxidant Dendrimers Derived from D-Mannitol and Syringaldehyde
  - PMID 40490897 (2025, Int J Cosmet Sci): Investigating the dual functions of butylated hydroxytoluene, vitamin E and vitamin C as antioxidants and anti-glycation
  - PMID 40250273 (2025, J Hazard Mater): Developmental toxicity and skin sensitization potential of synthetic phenolic antioxidants and butylated hydroxytoluene 

## 6. Linked PubMed Literature
- [PMID: 41303448] Synthesis and Evaluation of Powerful Antioxidant Dendrimers Derived from D-Mannitol and Syringaldehyde — *Int J Mol Sci* (2025)
- [PMID: 40490897] Investigating the dual functions of butylated hydroxytoluene, vitamin E and vitamin C as antioxidants and anti-glycation agents in vitro: Implications for skin health — *Int J Cosmet Sci* (2025)
- [PMID: 40250273] Developmental toxicity and skin sensitization potential of synthetic phenolic antioxidants and butylated hydroxytoluene transformation products: Insights from human embryonic stem cell models — *J Hazard Mater* (2025)
- [PMID: 39981196] Assessment of the feed additive consisting of canthaxanthin (Carophyll® Red 10%) for breeder hens for the renewal of its authorisation (DSM Nutritional Products Ltd.) — *EFSA J* (2025)
- [PMID: 42064523] Suprapubic Hair as a Supplementary Donor Source in Body Hair Follicular Unit Extraction: A Case Report — *Cureus* (2026)
- [PMID: 41475196] Optimizing oxidative stability of Camellia oleifera seed oil: Multimodal analysis of antioxidant efficacy, tocopherol loss, benzoapyrene suppression, and kinetic mechanisms — *Food Chem* (2026)
- [PMID: 41451025] Rheum officinale Baill.: chemical characterization and in-vitro biological activities — *Front Chem* (2025)
- [PMID: 41388507] Initiator-Free Supramolecular Zwitterionic Gels for Skin-Inspired Soft Iontronics — *Adv Mater* (2026)
- [PMID: 40259916] Biosynthesis and Characterization of ZnO Nanoparticles Using Citrus reticulata Peel Followed by Photocatalytic, Antibacterial, and Antioxidative Nanotherapeutic Attributes Assessment Supported by Computer Simulation — *Int J Nanomedicine* (2025)
- [PMID: 40164108] Audiological findings in patients with leprosy — *Acta Otolaryngol* (2025)
- [PMID: 40133211] Chromatographic Analysis, Antioxidant, Antimicrobial, Cytotoxic, and Antalgic Activities of Hydromethanolic Extract and Essential Oil From Inula viscosa L. Roots — *Chem Biodivers* (2025)
- [PMID: 39828415] An innovative approach for lipid-rich food preservation: peanut skin microcapsules — *J Food Sci* (2025)