# BARIUM SULFATE (barium-sulfate) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/barium-sulfate
- **Standard INCI**: `BARIUM SULFATE`
- **KR MFDS Standard Name**: `바륨설페이트`
- **CAS No.**: `7727-43-7`
- **EC / EINECS No.**: `231-784-4`
- **Origin**: `mineral`
- **Functions**: 색소, 불투명화제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 바륨설페이트 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | BARIUM SULFATE |
| US (PCPC / MoCRA INCI) | BARIUM SULFATE |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 硫酸钡 |
| JP (JCIA / MHLW QD) | BARIUM SULFATE  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `noted`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `4388`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- Listed within general cosmetic GMP safety thresholds.

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8
- **Max Process Temp**: ≤ 50°C
- **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL
- **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: BARIUM SULFATE | CAS No.: 7727-43-7 | EC No.: 231-784-4
  - Origin: MINERAL | Functions: , 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [BARIUM SULFATE] · EU [BARIUM SULFATE] · CN [硫酸钡] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - (CI 77120) Classified under origin 'mineral', it acts within the cosmetic vehicle or stratum corneum to deliver ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: NOTED | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 4388 (硫酸钡))
  - [EU / COMPOSITION / noted]: 
  - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [sun_color] Typical range: 1.08 ~ 5.0% (Median 3.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=11, GRANT 11)) — Sun care & color cosmetics dispersion / sensory modifier
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Cool-down Phase (< 45°C)
  - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads
  - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: BARIUM SULFATE
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 39227615 (2024, Sci Rep): Development and performance evaluation of medical radiation-reducing creams using eco-friendly radiation-shielding compo
  - PMID 26466182 (2015, Radiographics): Safe Use of Contrast Media: What the Radiologist Needs to Know.
  - PMID 41860133 (2026, Clin Transl Gastroenterol): Endoscopic Application of Tranexamic Acid and Sucralfate in Upper Gastrointestinal Bleeding: A Randomized Controlled Tri

## 6. Linked PubMed Literature
- [PMID: 39227615] Development and performance evaluation of medical radiation-reducing creams using eco-friendly radiation-shielding composites. — *Sci Rep* (2024)
- [PMID: 26466182] Safe Use of Contrast Media: What the Radiologist Needs to Know. — *Radiographics* (2015)
- [PMID: 41860133] Endoscopic Application of Tranexamic Acid and Sucralfate in Upper Gastrointestinal Bleeding: A Randomized Controlled Trial — *Clin Transl Gastroenterol* (2026)
- [PMID: 40439208] Evaluation of Zinc Oxide-Eugenol, Zinc Oxide-Propolis and Endoflas as an Obturating Materials in Primary Molar Pulpectomies - A Comparative Study — *Indian J Dent Res* (2025)
- [PMID: 35710385] No inflammatory effects after acute inhalation of barium sulfate particles in human volunteers — *BMC Pulm Med* (2022)
- [PMID: 35195793] An integrated approach to the bioavailability, ecological, and health risk assessment of potentially toxic elements in soils within a barite mining area, SE Nigeria — *Environ Monit Assess* (2022)
- [PMID: 35229325] Arterial supply to the scrotum: A cadaveric angiographic study — *Vet Surg* (2022)
- [PMID: 40489064] Axial pattern flaps based on the dorsal and ventral perineal arteries: A cadaveric study in dogs and a case report — *Vet Surg* (2026)
- [PMID: 38129303] Anatomical study of the architecture of the cutaneous branch-chained blood vessels in the medial lower leg in adult — *Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi* (2023)
- [PMID: 37109895] Performance Evaluation of Radiation-Shielding Materials and Process Technology for Manufacturing Skin Protection Cream — *Materials (Basel)* (2023)
- [PMID: 37050784] Pulse Oximetry Imaging System Using Spatially Uniform Dual Wavelength Illumination — *Sensors (Basel)* (2023)
- [PMID: 35591868] Video Endoscopy-Guided Intrabronchial Spray Inoculation of Mycobacterium bovis in Goats and Comparative Assessment of Lung Lesions With Various Imaging Methods — *Front Vet Sci* (2022)
- [PMID: 34905753] The Homodigital Propeller Flap: A New Tool for Fingertip Reconstruction. Surgical Technique, Anatomical Study, and Clinical Relevance — *Plast Reconstr Surg* (2022)