# ASIATICOSIDE (asiaticoside) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/asiaticoside
- **Standard INCI**: `ASIATICOSIDE`
- **KR MFDS Standard Name**: `아시아티코사이드`
- **CAS No.**: `16830-15-2`
- **EC / EINECS No.**: `240-851-7`
- **Origin**: `synthetic`
- **Functions**: 항산화제, 피부컨디셔닝제, 향료
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 아시아티코사이드 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | ASIATICOSIDE |
| US (PCPC / MoCRA INCI) | ASIATICOSIDE |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 积雪草苷 |
| JP (JCIA / MHLW QD) | アシアチコシド (QD: アシアチコシド) |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `3173`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- **cn_iecic_max** (leave_on): ≤ 1% — NMPA IECIC (2025) Entry 08354 (2025)
- **cn_iecic_max** (rinse_off): ≤ 0.5% — NMPA IECIC (2025) Entry 08354 (2025)

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4.5 – 7.5
- **Max Process Temp**: ≤ 70°C
- **Synergy Pairings**: —
- **Incompatibilities**: —

## 5. Academic Monograph
Asiaticoside is a triterpenoid compound extracted from Centella asiatica.
In diabetic wounds, it alleviates inflammation by activating ferroptosis of M1 macrophages through downregulation of ferroportin 1 (FPN1) and ferritin heavy chain 1 (FTH1)-induced degradation, which increases intracellular free ferrous ions (Fe2+).
It modulates signaling pathways including NF-κB, MAPK, Nrf2/HO-1, and TGF-β/Smad, demonstrating anti-inflammatory effects, reduction of oxidative stress, and fibrosis inhibition.
It promotes angiogenesis and enhances collagen synthesis to accelerate wound healing.
It promotes fibroblast proliferation and collagen production while enhancing fibroblast migration and wound closure rates.
When delivered through sustained-release systems such as gelatin-based biogels and nanofiber composite dressings, it exhibits antibacterial activity, anti-inflammatory effects, angiogenesis promotion, and collagen deposition.
In transdermal patch formulations, it achieves 95.2% or greater drug release over 12 hours and promotes wound contraction without skin irritation.
When encapsulated in transfersomal nanocarriers, it demonstrates improved skin penetration, anti-inflammatory activity, and regenerative potential compared to native formulations.

## 6. Linked PubMed Literature
- [PMID: 42280293] Geroprotective Potential of Centella asiatica: Modulation of Cellular Aging — *Nutrients* (2026)
- [PMID: 41866921] Therapeutic potential of Asiaticoside in wound healing after endoscopic submucosal dissection (ESD) — *Pharm Biol* (2026)
- [PMID: 41478185] Skin-inspired biogel/nanofiber composite dressing for sustained co-delivery of asiaticoside and zinc ions enabling synergistic burn wound healing — *J Colloid Interface Sci* (2026)
- [PMID: 41476651] Activating Ferroptosis of M1 Macrophages: A Novel Mechanism of Asiaticoside Encapsuled in GelMA for Anti-Inflammation in Diabetic Wounds — *Exploration (Beijing)* (2025)
- [PMID: 41460316] Development and optimization of asiaticoside co-crystal-loaded transdermal patch for topical therapy — *Naunyn Schmiedebergs Arch Pharmacol* (2026)
- [PMID: 41025315] Transfersomal delivery of Centella asiatica promotes efficient excision wound healing in rats — *Drug Deliv* (2025)
- [PMID: 41802486] A multi-target combinatorial therapy of MDBA alleviates atopic dermatitis via synchronized immunosuppression and barrier repair — *Eur J Pharmacol* (2026)
- [PMID: 41683503] Centella asiatica as a Model Biomass for Sustainable Production of Biochemicals via Green Extraction and Purification Technologies: A Comprehensive Field-to-Market Review — *Molecules* (2026)
- [PMID: 41574389] Enhancing Wound Healing with a Novel Alginate/Eggshell Membrane-Based Hydrogel Enriched with Red Ginseng Roots and Centella Asiatica — *Skin Res Technol* (2026)
- [PMID: 41534264] Synergistic intercellular junction and anti-inflammation wound healing therapy via bioengineered hybrid nanovesicles — *Biomaterials* (2026)
- [PMID: 41516082] Oral Centella asiatica Extract Attenuates UVB-Induced Skin Photoaging via Antioxidant, Anti-Inflammatory, and Extracellular Matrix-Preserving Effects in Hairless Mice — *Int J Mol Sci* (2025)
- [PMID: 41507645] Smart Stings of Nature: Harnessing Microneedles Assisted Targeted Phytoconstituent Delivery for Dermatological Disorders — *AAPS PharmSciTech* (2026)