# ASCORBYL TETRAISOPALMITATE (ascorbyl-tetraisopalmitate) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/ascorbyl-tetraisopalmitate
- **Standard INCI**: `ASCORBYL TETRAISOPALMITATE`
- **KR MFDS Standard Name**: `아스코빌테트라이소팔미테이트`
- **CAS No.**: `161436-56-2`
- **EC / EINECS No.**: `N/A`
- **Origin**: `vitamin`
- **Functions**: 항산화제, 에모리엔트
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 아스코빌테트라이소팔미테이트 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | ASCORBYL TETRAISOPALMITATE |
| US (PCPC / MoCRA INCI) | ASCORBYL TETRAISOPALMITATE |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 抗坏血酸四异棕榈酸酯 |
| JP (JCIA / MHLW QD) | テトラヘキシルデカン酸アスコルビル (QD: テトラ２－ヘキシルデカン酸アスコルビル) |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `noted`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `4106`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- **cn_iecic_max** (leave_on): ≤ 10% — NMPA IECIC (2025) Entry 03925 (2025)
- **cn_iecic_max** (rinse_off): ≤ 3% — NMPA IECIC (2025) Entry 03925 (2025)

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4.5 – 7.5
- **Max Process Temp**: ≤ 70°C
- **Synergy Pairings**: —
- **Incompatibilities**: —

## 5. Academic Monograph
Ascorbyl tetraisopalmitate is a vitamin C derivative with superior stability and transdermal absorption compared to vitamin C, functioning as a whitening ingredient.
This ingredient demonstrates melanogenesis inhibition through CREB-MITF signaling pathway suppression and synergistic activation of nicotinamide nucleotide transhydrogenase (NNT) gene expression.
In reactive oxygen species (ROS)-rich environments, it enables ROS-triggered release mechanisms to enhance antioxidant activity and promote wound healing.
When encapsulated in lyotropic liquid crystal nanoparticles, it achieves sustained release into skin, penetration through the stratum corneum to the dermis, tyrosinase activity inhibition, and reduced melanin production.
Combined with photoprotective formulations, it improves photoaged skin conditions by increasing skin hydration, dermis echogenicity, reducing hyperpigmentation, and enhancing epidermal cell renewal.
In combination with melatonin and bakuchiol within a 3-in-1 night serum, it demonstrates clinical and histological improvement in skin aging signs and significantly reduces UV-induced apoptotic sunburn cells.
Within the 3-in-1 serum formulation, it stimulates dermal protein synthesis including increased collagen I and III levels, procollagen type I precursor, and tropoelastin in dermal fibroblasts.

## 6. Linked PubMed Literature
- [PMID: 42093282] Determination of six whitening ingredients in cosmetics by ultra performance liquid chromatography coupled with photodiode array detector and corona charged aerosol detector — *Se Pu* (2026)
- [PMID: 41408899] The Combination of Pterocarpus marsupium Bark Extract, Pinus strobus Bark Extract, and Ascorbyl Tetraisopalmitate Inhibits Melanogenesis via Nicotinamide Nucleotide Transhydrogenase Activation — *J Cosmet Dermatol* (2025)
- [PMID: 40367861] Enhanced wound healing via ROS-triggered release of ascorbyl tetraisopalmitate loaded in ferrocene-based polymer nanoparticles — *Redox Biol* (2025)
- [PMID: 40143144] Usage Frequency and Ecotoxicity of Skin Depigmenting Agents — *Pharmaceuticals (Basel)* (2025)
- [PMID: 39870034] Biocompatible Lyotropic Nanocarriers for Improved Delivery of Ascorbyl Tetraisopalmitate in Skincare — *Langmuir* (2025)
- [PMID: 35625765] Combination of Glycinamide and Ascorbic Acid Synergistically Promotes Collagen Production and Wound Healing in Human Dermal Fibroblasts — *Biomedicines* (2022)
- [PMID: 33529350] Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study — *Photochem Photobiol* (2021)
- [PMID: 33151621] Efficacy of topical antioxidants in the skin hyperpigmentation control: A clinical study by reflectance confocal microscopy — *J Cosmet Dermatol* (2021)
- [PMID: 32061043] Efficacy and safety of a 3-in-1 antiaging night facial serum containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate through clinical and histological analysis — *J Cosmet Dermatol* (2020)
- [PMID: 31900804] Epidermal and Dermal Hallmarks of Photoaging are Prevented by Treatment with Night Serum Containing Melatonin, Bakuchiol, and Ascorbyl Tetraisopalmitate: In Vitro and Ex Vivo Studies — *Dermatol Ther (Heidelb)* (2020)
- [PMID: 31099952] Determining the effectiveness of vitamin C in skin care by atomic force microscope — *Microsc Res Tech* (2019)
- [PMID: 38539863] Multifaceted Effects of L-Cysteine, L-Ascorbic Acid, and Their Derivatives on the Viability and Melanin Synthesis of B16/F10 Cells under Different Conditions — *Antioxidants (Basel)* (2024)