# ARGANIA SPINOSA KERNEL OIL (argania-spinosa-kernel-oil) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/argania-spinosa-kernel-oil
- **Standard INCI**: `ARGANIA SPINOSA KERNEL OIL`
- **KR MFDS Standard Name**: `아르간커넬오일`
- **CAS No.**: `223747-87-3`
- **EC / EINECS No.**: `N/A`
- **Origin**: `plant`
- **Functions**: 피부컨디셔닝제, 에모리엔트
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 아르간커넬오일 |
| KR (Former Names) | 아르간트리커넬오일 |
| EU (CosIng 1223/2009) | ARGANIA SPINOSA KERNEL OIL |
| US (PCPC / MoCRA INCI) | ARGANIA SPINOSA KERNEL OIL |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 刺阿干树(ARGANIA SPINOSA)仁油 |
| JP (JCIA / MHLW QD) | ARGANIA SPINOSA KERNEL OIL  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `1704`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- Listed within general cosmetic GMP safety thresholds.

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8
- **Max Process Temp**: ≤ 50°C
- **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL
- **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: ARGANIA SPINOSA KERNEL OIL | CAS No.: 223747-87-3 | EC No.: N/A
  - Origin: PLANT | Functions: Skin Conditioning, 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [ARGANIA SPINOSA KERNEL OIL] · EU [ARGANIA SPINOSA KERNEL OIL] · CN [刺阿干树(ARGANIA SPINOSA)仁油] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - Argania Spinosa Kernel Oil is the fixed oil expressed from the kernels, Argania Spinosa (L.), Sapotaceae Classified under origin 'plant', it acts within the cosmetic vehicle or stratum corneum to deliver ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 1704 (刺阿干树(ARGANIA SPINOSA)仁油))
  - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment).
  - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [emulsion_cream] Typical range: 0.5 ~ 4.0% (Median 2.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=15, GRANT 11 · SEPPIC 4)) — Emulsion cream & lotion structural / conditioning agent
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Cool-down Phase (< 45°C)
  - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads
  - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: ARGANIA SPINOSA KERNEL OIL
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 41134387 (2025, Lasers Med Sci): Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Pa
  - PMID 33811776 (2022, J Cosmet Dermatol): A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spe
  - PMID 24797024 (2014, J Cosmet Sci): Oxidative stability of cosmetic argan oil: a one-year study

## 6. Linked PubMed Literature
- [PMID: 41134387] Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial — *Lasers Med Sci* (2025)
- [PMID: 33811776] A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low-potency topical corticosteroid in the treatment of intertrigo — *J Cosmet Dermatol* (2022)
- [PMID: 24797024] Oxidative stability of cosmetic argan oil: a one-year study — *J Cosmet Sci* (2014)