# ANHYDROXYLITOL (anhydroxylitol) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/anhydroxylitol
- **Standard INCI**: `ANHYDROXYLITOL`
- **KR MFDS Standard Name**: `안하이드로자일리톨`
- **CAS No.**: `53448-53-6`
- **EC / EINECS No.**: `258-560-9`
- **Origin**: `synthetic`
- **Functions**: 보습제, 피부컨디셔닝제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 안하이드로자일리톨 |
| KR (Former Names) | 무수자일리톨 |
| EU (CosIng 1223/2009) | ANHYDROXYLITOL |
| US (PCPC / MoCRA INCI) | ANHYDROXYLITOL |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 脱水木糖醇 |
| JP (JCIA / MHLW QD) | ANHYDROXYLITOL  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `6749`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- Listed within general cosmetic GMP safety thresholds.

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8
- **Max Process Temp**: ≤ 50°C
- **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL
- **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: ANHYDROXYLITOL | CAS No.: 53448-53-6 | EC No.: 258-560-9
  - Origin: SYNTHETIC | Functions: , 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [ANHYDROXYLITOL] · EU [ANHYDROXYLITOL] · CN [脱水木糖醇] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - ANHYDROXYLITOL functions primarily as ,  in dermatological and cosmetic formulations. Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 6749 (脱水木糖醇))
  - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment).
  - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [aqueous_serum] Typical range: 1.0 ~ 3.0% (Median 3.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=9, SEPPIC 9)) — Aqueous serum, toner & hydrogel matrix formulation component
  - [cleanser_rinse] Typical range: 1.0 ~ 3.0% (Median 1.75%, Ref: Global Starter Formulation Library Statistical Distribution (n=6, SEPPIC 6)) — Rinse-off cleanser & surfactant system modifier
  - [emulsion_cream] Typical range: 1.0 ~ 3.0% (Median 3.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=20, SEPPIC 20)) — Emulsion cream & lotion structural / conditioning agent
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Cool-down Phase (< 45°C)
  - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads
  - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: ANHYDROXYLITOL
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 41243164 (2025, Int J Toxicol): Safety Assessment of Anhydrogalactose, Anhydroglucitol, Anhydroxylitol, Arabinose, Psicose, Saccharide Hydrolysate, and 
  - PMID 36541033 (2023, Skin Res Technol): Evaluation of a new connected portable camera for the analysis of skin microrelief and the assessment of the effect of s
  - PMID 19250164 (2009, J Cosmet Dermatol): Hydrating effects of moisturizer active compounds incorporated into hydrogels: in vivo assessment and comparison between

## 6. Linked PubMed Literature
- [PMID: 41243164] Safety Assessment of Anhydrogalactose, Anhydroglucitol, Anhydroxylitol, Arabinose, Psicose, Saccharide Hydrolysate, and Saccharide Isomerate as Used in Cosmetics — *Int J Toxicol* (2025)
- [PMID: 36541033] Evaluation of a new connected portable camera for the analysis of skin microrelief and the assessment of the effect of skin moisturisers — *Skin Res Technol* (2023)
- [PMID: 19250164] Hydrating effects of moisturizer active compounds incorporated into hydrogels: in vivo assessment and comparison between devices — *J Cosmet Dermatol* (2009)
- [PMID: 1831974] Kinetic studies of Mg(2+)-, Co(2+)- and Mn(2+)-activated D-xylose isomerases — *Biochem J* (1991)