# AMMONIUM LAURYL SULFATE (ammonium-lauryl-sulfate) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/ammonium-lauryl-sulfate
- **Standard INCI**: `AMMONIUM LAURYL SULFATE`
- **KR MFDS Standard Name**: `암모늄라우릴설페이트`
- **CAS No.**: `2235-54-3`
- **EC / EINECS No.**: `218-793-9`
- **Origin**: `synthetic`
- **Functions**: 세정제, 기포형성제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 암모늄라우릴설페이트 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | AMMONIUM LAURYL SULFATE |
| US (PCPC / MoCRA INCI) | AMMONIUM LAURYL SULFATE |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 月桂醇硫酸酯铵 |
| JP (JCIA / MHLW QD) | AMMONIUM LAURYL SULFATE  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `8343`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- Listed within general cosmetic GMP safety thresholds.

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8
- **Max Process Temp**: ≤ 50°C
- **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL
- **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: AMMONIUM LAURYL SULFATE | CAS No.: 2235-54-3 | EC No.: 218-793-9
  - Origin: SYNTHETIC | Functions: , 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [AMMONIUM LAURYL SULFATE] · EU [AMMONIUM LAURYL SULFATE] · CN [月桂醇硫酸酯铵] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - AMMONIUM LAURYL SULFATE functions primarily as ,  in dermatological and cosmetic formulations. Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 8343 (月桂醇硫酸酯铵))
  - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment).
  - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [cleanser_rinse] Typical range: 6.0 ~ 30.0% (Median 13.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=5, ELEMENTIS 3 · EVONIK 1 · SEPPIC 1)) — Rinse-off cleanser & surfactant system modifier
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Cool-down Phase (< 45°C)
  - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads
  - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: AMMONIUM LAURYL SULFATE
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 34577098 (2021, Molecules): Soapwort (Saponaria officinalis L.) Extract vs. Synthetic Surfactants-Effect on Skin-Mimetic Models
  - PMID 20448271 (2010, Int J Toxicol): Final report on the safety assessment of sodium cetearyl sulfate and related alkyl sulfates as used in cosmetics
  - PMID 7395740 (1980, Am Ind Hyg Assoc J): Effects of pyrithiones and surfactants on zinc and enzyme levels in rabbits

## 6. Linked PubMed Literature
- [PMID: 34577098] Soapwort (Saponaria officinalis L.) Extract vs. Synthetic Surfactants-Effect on Skin-Mimetic Models — *Molecules* (2021)
- [PMID: 20448271] Final report on the safety assessment of sodium cetearyl sulfate and related alkyl sulfates as used in cosmetics — *Int J Toxicol* (2010)
- [PMID: 7395740] Effects of pyrithiones and surfactants on zinc and enzyme levels in rabbits — *Am Ind Hyg Assoc J* (1980)
- [PMID: 755672] The determination of the irritancy potential of surfactants using various methods of assessment — *Drug Chem Toxicol* (1978)
- [PMID: 20523770] The Effect of Detergents on the Morphology and Immunomodulatory Activity of Malassezia furfur — *Ann Dermatol* (2009)