# AMARANTHUS CAUDATUS SEED EXTRACT (amaranthus-caudatus-seed-extract) — Global Cosmetic Regulatory & Formulation Monograph - **Canonical URL**: https://www.inciname.com/en/ingredients/amaranthus-caudatus-seed-extract - **Standard INCI**: `AMARANTHUS CAUDATUS SEED EXTRACT` - **KR MFDS Standard Name**: `줄맨드라미씨추출물` - **CAS No.**: `223747-79-3` - **EC / EINECS No.**: `N/A` - **Origin**: `plant` - **Functions**: 피부컨디셔닝제 - **Molecular Formula / MW**: `—` (— g/mol) ## 1. 7-Track Official Regulatory Label Names | Track | Official Label Nomenclature | | :--- | :--- | | KR (MFDS Standard) | 줄맨드라미씨추출물 | | KR (Former Names) | — | | EU (CosIng 1223/2009) | AMARANTHUS CAUDATUS SEED EXTRACT | | US (PCPC / MoCRA INCI) | AMARANTHUS CAUDATUS SEED EXTRACT | | US (FDA OTC Monograph) | — | | CN (NMPA IECIC) | 尾穗苋(AMARANTHUS CAUDATUS)籽提取物 | | JP (JCIA / MHLW QD) | AMARANTHUS CAUDATUS SEED EXTRACT | ## 2. Layer 1 — Global 6-Region Statutory Summary - **KR (MFDS)**: `none` - **EU (1223/2009)**: `none` - **US (FDA/MoCRA)**: `none` - **CN (NMPA IECIC)**: `allowed` (Entry: `6791`) - **JP (MHLW)**: `none` - **ASEAN (ACD)**: `none` ## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations - Listed within general cosmetic GMP safety thresholds. ## 4. Layer 3 — Formulation Quartiles & Compatibility - **Optimal pH Window**: 4 – 8 - **Max Process Temp**: ≤ 50°C - **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL - **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads ## 5. Academic Monograph ■ [1. Chemical Identity & International Labeling Nomenclature] - INCI Name: AMARANTHUS CAUDATUS SEED EXTRACT | CAS No.: 223747-79-3 | EC No.: N/A - Origin: PLANT | Functions: Skin Conditioning - Physicochemical Profile: Formula | MW /(Polymer/Complex) | / | Ionic Nature: non-ionic | CosIng/MFDS - Official Regional Label Names: US [AMARANTHUS CAUDATUS SEED EXTRACT] · EU [AMARANTHUS CAUDATUS SEED EXTRACT] · CN [尾穗苋(AMARANTHUS CAUDATUS)籽提取物] · JP [-] · JP Quasi-Drug [-] ■ [2. Dermatological Mechanism of Action & Functional Role] - Amaranthus Caudatus Seed Extract is an extract of the seeds of Amaranthus caudatus L., Amaranthaceae Classified under origin 'plant', it acts within the cosmetic vehicle or stratum corneum to deliver performance and structural formulation stability. ■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)] - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 6791 (尾穗苋(AMARANTHUS CAUDATUS)籽提取物)) - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment). - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins ■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)] - [emulsion_cream] Typical range: 0.8 ~ 4.5% (Median 2.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=8, EVONIK 8)) — Emulsion cream & lotion structural / conditioning agent ■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)] - Addition Phase: Water Phase or Cool-down Phase (< 45°C) - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: AMARANTHUS CAUDATUS SEED EXTRACT ■ [6. Peer-Reviewed Literature & Official Compendia Evidence] - PMID 41601868 (2025, Front Nutr): Preliminary evaluation of an extract of Amaranthus caudatus as a novel nutraceutical: effects on cholesterol and glucose - PMID 41519619 (2026, Nutr Metab Cardiovasc Dis): Improved HDL, LDL and total cholesterol levels following a 3-month administration of Mentha spicata leaf extract and Ama - PMID 39456755 (2024, Int J Mol Sci): Effect of Sprouting, Fermentation and Cooking on Antioxidant Content and Total Antioxidant Activity in Quinoa and Amaran ## 6. Linked PubMed Literature - [PMID: 41601868] Preliminary evaluation of an extract of Amaranthus caudatus as a novel nutraceutical: effects on cholesterol and glucose absorption — *Front Nutr* (2025) - [PMID: 41519619] Improved HDL, LDL and total cholesterol levels following a 3-month administration of Mentha spicata leaf extract and Amaranthus caudatus seed flour extracts, flavonoids and B vitamins. A placebo-controlled, double-blind, randomized clinical trial — *Nutr Metab Cardiovasc Dis* (2026) - [PMID: 39456755] Effect of Sprouting, Fermentation and Cooking on Antioxidant Content and Total Antioxidant Activity in Quinoa and Amaranth — *Int J Mol Sci* (2024) - [PMID: 35466427] Obtaining biologically active substances from Amaranthus caudatus L. seeds in one technological cycle — *Biomed Chromatogr* (2022) - [PMID: 28114838] Antioxidative activities and phenolic compounds of pumpkin (Cucurbita pepo) seeds and amaranth (Amaranthus caudatus) grain extracts — *Nat Prod Res* (2017) - [PMID: 25639718] Radical Scavenging Activities of Tannin Extracted from Amaranth (Amaranthus caudatus L.) — *J Microbiol Biotechnol* (2015) - [PMID: 15930754] In Vitro antioxidant effect and inhibition of alpha-amylase of two varieties of Amaranthus caudatus seeds — *Biol Pharm Bull* (2005) - [PMID: 12918869] Rapid techniques for the extraction of vitamin E isomers from Amaranthus caudatus seeds: ultrasonic and supercritical fluid extraction — *Phytochem Anal* (2002) - [PMID: 12108218] Antioxidant activity of ethanolic extracts of amaranth seeds — *Nahrung* (2002) - [PMID: 11714343] Wild Amaranthus caudatus seed oil, a nutraceutical resource from Ecuadorian flora — *J Agric Food Chem* (2001)