# ALCOHOL DENAT. (alcohol-denat) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/alcohol-denat
- **Standard INCI**: `ALCOHOL DENAT.`
- **KR MFDS Standard Name**: `변성알코올`
- **CAS No.**: `64-17-5`
- **EC / EINECS No.**: `200-578-6`
- **Origin**: `synthetic`
- **Functions**: 항균제, 수렴제, 향료, 용제, 소포제, 점도조절제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 변성알코올 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | ALCOHOL DENAT. |
| US (PCPC / MoCRA INCI) | ALCOHOL DENAT. |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 变性乙醇 |
| JP (JCIA / MHLW QD) | ALCOHOL DENAT.  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `1365`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- Listed within general cosmetic GMP safety thresholds.

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8
- **Max Process Temp**: ≤ 50°C
- **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL
- **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: ALCOHOL DENAT. | CAS No.: 64-17-5 | EC No.: 200-578-6
  - Origin: SYNTHETIC | Functions: , , , , , 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [ALCOHOL DENAT.] · EU [ALCOHOL DENAT.] · CN [变性乙醇] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - Alcohol Denat. is ethyl alcohol that is denatured with one or more denaturing agents in accordance with the national legislation of each European Community (EU) country. Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver , , , , ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 1365 (变性乙醇))
  - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment).
  - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [aqueous_serum] Typical range: 3.0 ~ 10.0% (Median 4.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=5, EVONIK 5)) — Aqueous serum, toner & hydrogel matrix formulation component
  - [emulsion_cream] Typical range: 3.0 ~ 45.0% (Median 10.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=32, EVONIK 32)) — Emulsion cream & lotion structural / conditioning agent
  - [sun_color] Typical range: 0.32 ~ 8.0% (Median 3.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=12, EVONIK 11 · GRANT 1)) — Sun care & color cosmetics dispersion / sensory modifier
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Cool-down Phase (< 45°C)
  - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads
  - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: ALCOHOL DENAT.
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 18569160 (2008, Int J Toxicol): Final report of the safety assessment of Alcohol Denat., including SD Alcohol 3-A, SD Alcohol 30, SD Alcohol 39, SD Alco

## 6. Linked PubMed Literature
- [PMID: 18569160] Final report of the safety assessment of Alcohol Denat., including SD Alcohol 3-A, SD Alcohol 30, SD Alcohol 39, SD Alcohol 39-B, SD Alcohol 39-C, SD Alcohol 40, SD Alcohol 40-B, and SD Alcohol 40-C, and the denaturants, Quassin, Brucine Sulfate/Brucine, and Denatonium Benzoate — *Int J Toxicol* (2008)