# ACRYLAMIDE (acrylamide) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/acrylamide
- **Standard INCI**: `ACRYLAMIDE`
- **KR MFDS Standard Name**: `—`
- **CAS No.**: `79-06-1`
- **EC / EINECS No.**: `201-173-7`
- **Origin**: `synthetic`
- **Functions**: 미분류
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | — |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | ACRYLAMIDE |
| US (PCPC / MoCRA INCI) | ACRYLAMIDE |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | — |
| JP (JCIA / MHLW QD) | ACRYLAMIDE  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `banned`
- **EU (1223/2009)**: `banned`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `banned` (Entry: `—`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`

- **KR** [banned]: — —  (화장품 안전기준 등에 관한 규정 [별표1] 사용할 수 없는 원료)
- **EU** [banned]: — —  (Regulation (EC) No 1223/2009 Annex II — via CosIng (EU Commission))
- **CN** [banned]: — —  (化妆品禁用原料目录 (NMPA 공고 2021년 제74호))

## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- Listed within general cosmetic GMP safety thresholds.

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8
- **Max Process Temp**: ≤ 50°C
- **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL
- **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: ACRYLAMIDE | CAS No.: 79-06-1 | EC No.: 201-173-7
  - Origin: SYNTHETIC | Functions: 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [ACRYLAMIDE] · EU [ACRYLAMIDE] · CN [-] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - ACRYLAMIDE functions primarily as  in dermatological and cosmetic formulations. Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: BANNED | EU: BANNED | US: NONE | CN: BANNED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. Unlisted (-))
  - [KR / COMPOSITION / banned]: 
  - [CN / COMPOSITION / banned]: 
  - [EU / COMPOSITION / banned]: 
  - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [aqueous_serum] Typical range: 0.6 ~ 4.0% (Median 3.2%, Ref: Global Starter Formulation Library Statistical Distribution (n=5, GRANT 4 · SEPPIC 1)) — Aqueous serum, toner & hydrogel matrix formulation component
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Cool-down Phase (< 45°C)
  - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads
  - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: ACRYLAMIDE
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - Validated against official regulatory compendia (MFDS/CosIng/CIR/SCCS) and physicochemical standards.

## 6. Linked PubMed Literature