# 1,2-HEXANEDIOL (1-2-hexanediol) — Global Cosmetic Regulatory & Formulation Monograph - **Canonical URL**: https://www.inciname.com/en/ingredients/1-2-hexanediol - **Standard INCI**: `1,2-HEXANEDIOL` - **KR MFDS Standard Name**: `1,2-헥산다이올` - **CAS No.**: `6920-22-5` - **EC / EINECS No.**: `230-029-6` - **Origin**: `synthetic` - **Functions**: 피부컨디셔닝제, 용제 - **Molecular Formula / MW**: `C6H14O2` (118.17 g/mol) ## 1. 7-Track Official Regulatory Label Names | Track | Official Label Nomenclature | | :--- | :--- | | KR (MFDS Standard) | 1,2-헥산다이올 | | KR (Former Names) | 1, 2-헥산디올 | | EU (CosIng 1223/2009) | 1,2-HEXANEDIOL | | US (PCPC / MoCRA INCI) | 1,2-HEXANEDIOL | | US (FDA OTC Monograph) | — | | CN (NMPA IECIC) | 1,2-己二醇 | | JP (JCIA / MHLW QD) | １，２－ヘキサンジオール (QD: １，２－ヘキサンジオール) | ## 2. Layer 1 — Global 6-Region Statutory Summary - **KR (MFDS)**: `none` - **EU (1223/2009)**: `none` - **US (FDA/MoCRA)**: `none` - **CN (NMPA IECIC)**: `allowed` (Entry: `4`) - **JP (MHLW)**: `none` - **ASEAN (ACD)**: `none` ## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations - **reported_use** (total): 0.00005~10% — 116_tent_capryl.pdf (null) - **reported_use** (bath): 0.0004~0.2% — 116_tent_capryl.pdf (null) - **reported_use** (eye): 0.3~0.7% — 116_tent_capryl.pdf (null) - **reported_use** (dermal): 0.00005~10% — 116_tent_capryl.pdf (null) - **reported_use** (hair): 0.0003~0.3% — 116_tent_capryl.pdf (null) - **reported_use** (leave_on): 0.2~10% — 117_draft_cg.pdf (null) - **reported_use** (ingestion): 0.3~0.3% — 119_final_12glc.pdf (null) - **reported_use** (spray): 10~10% — 119_final_12glc.pdf (null) - **reported_use** (nail): 0.4~0.4% — 119_final_12glc.pdf (null) - **reported_use** (mucous): 0.3~0.3% — 119_final_12glc.pdf (null) - **reported_use** (rinse_off): 0.00005~0.8% — 119_final_12glc.pdf (null) - **cn_iecic_max** (leave_on): ≤ 15% — NMPA IECIC (2025) Entry 00004 (2025) - **cn_iecic_max** (rinse_off): ≤ 10% — NMPA IECIC (2025) Entry 00004 (2025) ## 4. Layer 3 — Formulation Quartiles & Compatibility - **Optimal pH Window**: 3 – 10 - **Max Process Temp**: ≤ 80°C - **Synergy Pairings**: ETHYLHEXYLGLYCERIN, HYDROXYACETOPHENONE, PENTYLENE GLYCOL, CAPRYLYL GLYCOL - **Incompatibilities**: Concentrations > 2.2% may reduce emulsion viscosity due to interfacial partitioning; pair with 0.05% Ethylhexylglycerin ## 5. Academic Monograph ■ [1. Chemical Identity & International Labeling Nomenclature] - INCI Name: 1,2-HEXANEDIOL | CAS No.: 6920-22-5 | EC No.: 230-029-6 - Origin: SYNTHETIC | Functions: Skin Conditioning, - Physicochemical Profile: Formula C6H14O2 | MW 118.17 g/mol | LogP 0.6 | Ionic Nature: non-ionic | PubChem CID 13583 - Official Regional Label Names: US [1,2-HEXANEDIOL] · EU [1,2-HEXANEDIOL] · CN [1,2-己二醇] · JP [１，２－ヘキサンジオール] · JP Quasi-Drug [１，２－ヘキサンジオール] ■ [2. Dermatological Mechanism of Action & Functional Role] - 1,2-HEXANEDIOL functions primarily as , in dermatological and cosmetic formulations. Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver , performance and structural formulation stability. ■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)] - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 4 (1,2-己二醇)) - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment). - Official Safety & Historical Use Concentration (Layer 2): cir (reported_use, total): 5e-05~10% / cir (reported_use, bath): 0.0004~0.2% / cir (reported_use, eye): 0.3~0.7% ■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)] - [aqueous_serum] Typical range: 0.5 ~ 3.0% (Median 2.0%, Ref: CIR Alkane Diols Safety Assessment & CN IECIC) — pH-independent antimicrobial humectant & solvent booster - [emulsion_cream] Typical range: 0.5 ~ 2.5% (Median 1.8%, Ref: CIR 1,2-Hexanediol Assessment) — Preservative-free system main diol booster ■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)] - Addition Phase: Water Phase or Cool-down Phase (< 80°C) - Optimal pH Range: pH 3.0 ~ 10.0 | Max Process Temp: Max 80°C | Electrolyte Tolerance: HIGH - Incompatibility / Caution: Concentrations > 2.2% may reduce emulsion viscosity due to interfacial partitioning; pair with 0.05% Ethylhexylglycerin - Synergy Pairings: ETHYLHEXYLGLYCERIN, HYDROXYACETOPHENONE, PENTYLENE GLYCOL, CAPRYLYL GLYCOL | Reference Trade Names: SymDiol® 68 (with Caprylyl Glycol), Hydrolite® 6 ■ [6. Peer-Reviewed Literature & Official Compendia Evidence] - PMID 39805611 (2024, J Microorg Control): Synergistic/antagonistic antimicrobial effects of cosmetic ingredients in combination with 1,2-hexanediol - PMID 39248485 (2024, J Vis Exp): Microwave-Assisted Extraction of Phenolic Compounds and Antioxidants for Cosmetic Applications Using Polyol-Based Techno - PMID 39203006 (2024, Molecules): New Natural and Sustainable Cosmetic Preservative Based on Sugarcane Straw Extract ## 6. Linked PubMed Literature - [PMID: 39805611] Synergistic/antagonistic antimicrobial effects of cosmetic ingredients in combination with 1,2-hexanediol — *J Microorg Control* (2024) - [PMID: 39248485] Microwave-Assisted Extraction of Phenolic Compounds and Antioxidants for Cosmetic Applications Using Polyol-Based Technology — *J Vis Exp* (2024) - [PMID: 39203006] New Natural and Sustainable Cosmetic Preservative Based on Sugarcane Straw Extract — *Molecules* (2024) - [PMID: 39153997] Deciphering trends in replacing preservatives in cosmetics intended for infants and sensitive population — *Sci Rep* (2024) - [PMID: 35509819] Influence of Panax ginseng formulation on skin microbiota: A randomized, split face comparative clinical study — *J Ginseng Res* (2022) - [PMID: 34575527] Impact of Alkanediols on Stratum Corneum Lipids and Triamcinolone Acetonide Skin Penetration — *Pharmaceutics* (2021) - [PMID: 32505050] Assessment of the potential risk of 1,2-hexanediol using phytotoxicity and cytotoxicity testing — *Ecotoxicol Environ Saf* (2020) - [PMID: 32057889] Topical delivery of niacinamide: Influence of neat solvents — *Int J Pharm* (2020) - [PMID: 31517290] 3-O-ethyl-l-ascorbic acid: Characterisation and investigation of single solvent systems for delivery to the skin — *Int J Pharm X* (2019) - [PMID: 35423975] Insights into the structure of sunscreen lotions: a small-angle neutron scattering study — *RSC Adv* (2021) - [PMID: 34216765] The effect of alkanediols on the release of triamcinolone acetonide from semisolid dosage forms — *Int J Pharm* (2021) - [PMID: 33233527] Investigations on Alkanediols as Alternative Preservatives in a Nonionic Hydrophilic Cream — *Pharmaceutics* (2020)